In vitro and In vivo Activity of 2 - Aminopyrazines / 2 - 1 Aminopyridines in Experimental Models of Human African 2 Trypanosomiasis 3
نویسندگان
چکیده
Department of Pharmacy, Uppsala University Drug Optimization and 11 Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, 12 Uppsala University, Uppsala, Sweden 13 *Corresponding Author. Current address: Chemical Biology Consortium 14 Sweden, Science for Life Laboratory, Division of Translational Medicine and 15 Chemical Biology, Department of Medical Biochemistry 15 and Biophysics, 16 SE171 77 Karolinska Institutet, Stockholm, Sweden. Web: www.cbcs.se/lcbki, 17 Phone: +46-8-524-87768. Email: [email protected] 18
منابع مشابه
In vitro and in vivo activities of 2-aminopyrazines and 2-aminopyridines in experimental models of human African trypanosomiasis.
New drugs for the treatment of human African trypanosomiasis are urgently needed. A number of 2-aminopyrazines/2-aminopyridines were identified as promising leads following a focused screen of 5,500 compounds for Trypanosoma brucei subsp. brucei viability. Described compounds are trypanotoxic in the submicromolar range and show comparably low cytotoxicity on representative mammalian cell lines....
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